Miles S. Congreve: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

1

Crystal structure of the GLP-1 receptor bound to a peptide agonist

Jazayeri, Ali, Rappas, Mathieu, Brown, Alastair J. H., Kean, James, Errey, James C., Robertson, Nathan J., Fiez-Vandal, Cédric, Andrews, Stephen P., Congreve, Miles, Bortolato, Andrea, Mason, Jonathan

Journal:

Year:

2017

Language:

english

File:

PDF, 6.41 MB

english, 2017

2

A ‘Rule of Three’ for fragment-based lead discovery?

Miles Congreve, Robin Carr, Chris Murray, Harren Jhoti

Journal:

Drug Discovery Today

Year:

2003

Language:

english

File:

PDF, 24 KB

english, 2003

3

Identification of a novel allosteric GLP–1R antagonist HTL26119 using structure- based drug design

O'Brien, Alistair, Andrews, Steve, Baig, Asma H., Bortolato, Andrea, J. H. Brown, Alastair, Brown, Giles A., Brown, Sue H., Christopher, John A., Congreve, Miles, Cooke, Robert M., De Graaf, Chris, Er

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 1.15 MB

english, 2019

4

Impact of GPCR Structures on Drug Discovery

Congreve, Miles, de Graaf, Chris, Swain, Nigel A., Tate, Christopher G.

Journal:

Year:

2020

File:

PDF, 2.58 MB

2020

5

Fragment-based lead discovery

Rees, David C., Congreve,, Miles, Murray, Christopher W., Carr, Robin

Journal:

Nature Reviews Drug Discovery

Year:

2004

Language:

english

File:

PDF, 283 KB

english, 2004

6

The impact of GPCR structures on pharmacology and structure-based drug design

Miles Congreve, Fiona Marshall

Journal:

British Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 390 KB

english, 2010

7

Keynote review: Structural biology and drug discovery

Miles Congreve, Christopher W. Murray, Tom L. Blundell

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 238 KB

english, 2005

8

Perspective in Medicinal Chemistry: Structure-Based Drug Design

Congreve, Miles, Andrews, Steve

Journal:

Current Topics in Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 636 KB

english, 2016

9

Recent Developments in Fragment-Based Drug Discovery

Congreve, Miles, Chessari, Gianni, Tisi, Dominic, Woodhead, Andrew J.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 3.59 MB

english, 2008

10

Progress in Structure Based Drug Design for G Protein-Coupled Receptors

Congreve, Miles, Langmead, Christopher J., Mason, Jonathan S., Marshall, Fiona H.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 10.73 MB

english, 2011

11

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Woodhead, Andrew J., Angove, Hayley, Carr, Maria G., Chessari, Gianni, Congreve, Miles, Coyle, Joseph E., Cosme, Jose, Graham, Brent, Day, Philip J., Downham, Robert, Fazal, Lynsey, Feltell, Ruth, Fig

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.98 MB

english, 2010

12

Recent Developments in Therapeutic Peptides for the Glucagon-like Peptide 1 and 2 Receptors

Suzuki, Rie, Brown, Giles, Christopher, John A., Scully, Conor, Congreve, Miles

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 2.32 MB

english, 2019

13

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

Andrew S. Doré, Nathan Robertson, James C. Errey, Irene Ng, Kaspar Hollenstein, Ben Tehan, Edward Hurrell, Kirstie Bennett, Miles Congreve, Francesca Magnani, Christopher G. Tate, Malcolm Weir, Fiona

Journal:

Year:

2011

Language:

english

File:

PDF, 1.31 MB

english, 2011

14

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Murray, Christopher W., Carr, Maria G., Callaghan, Owen, Chessari, Gianni, Congreve, Miles, Cowan, Suzanna, Coyle, Joseph E., Downham, Robert, Figueroa, Eva, Frederickson, Martyn

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.37 MB

english, 2010

15

Single Bead Characterization Using Analytical Constructs: Application to Quality Control of Libraries

Lorthioir, Olivier, Carr, Robin A. E., Congreve, Miles S., Geysen, Mario H., Kay, Corinne, Marshall, Peter, McKeown, Stephen C., Parr, Nigel J., Scicinski, Jan J., Watson, Stephen P.

Journal:

Analytical Chemistry

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

16

Allosteric binding: structures reveal new ways to tame G protein-coupled receptors

Cooke, Robert, Congreve, Miles

Journal:

Future Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.28 MB

english, 2016

17

Analysis of Solid-Phase Reactions: Product Identification and Quantification by Use of UV-Chromophore-Containing Dual-Linker Analytical Constructs

Geoff M. Williams, Robin A. E. Carr, Miles S. Congreve, Corinne Kay, Stephen C. McKeown, Peter J. Murray, Jan J. Scicinski, Stephen P. Watson

Journal:

Angewandte Chemie International Edition

Year:

2000

Language:

english

File:

PDF, 191 KB

english, 2000

18

Fragment-based lead discovery: leads by design

Robin A.E. Carr, Miles Congreve, Christopher W. Murray, David C. Rees

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 134 KB

english, 2005

19

Recent Developments in Therapeutic Peptides for the Glucagon-like Peptide 1 and 2 Receptors

Suzuki, Rie, Brown, Giles, Christopher, John A., Scully, Conor, Congreve, Miles

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 2.32 MB

2019

20

ChemInform Abstract: Analytical Construct Resins for Analysis of Solid-Phase Chemistry

Miles S. Congreve, Steven V. Ley, Jan J. Scicinski

Journal:

Year:

2002

File:

PDF, 25 KB

2002

21

Versatile solid-phase synthesis of secondary amines from alcohols. Development of an N-Boc-(o-nitrobenzene)sulfonamide linker

Miles S. Congreve, Corinne Kay, Jan J. Scicinski, Steven V. Ley, Geoffrey Williams, Peter J. Murray, Stephen C. McKeown, Stephen P. Watson

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 256 KB

english, 2003

22

Identification of Novel Adenosine A 2A Receptor Antagonists by Virtual Screening

Langmead, Christopher J., Andrews, Stephen P., Congreve, Miles, Errey, James C., Hurrell, Edward, Marshall, Fiona H., Mason, Jonathan S., Richardson, Christine M., Robertson, Nathan, Zhukov, Andrei, W

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 277 KB

english, 2012

23

A novel phase-switching protecting group for multi-step parallel solution phase synthesis

Li, Xin, Abell, Chris, Congreve, Miles S., Warrington, Brian H., Ladlow, Mark

Journal:

Organic & Biomolecular Chemistry

Year:

2004

Language:

english

File:

PDF, 254 KB

english, 2004

24

Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

Gill, Adrian L., Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J., Carr, Maria G., Woodhead, Andrew J., Walker, Margaret T., Congreve, Miles S., Devine, Lindsay A., Tisi, Dominic, O'Reilly, Ma

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 686 KB

english, 2005

25

Targeting adenosine A 2A receptor antagonism for treatment of cancer

Congreve, Miles, Brown, Giles A., Borodovsky, Alexandra, Lamb, Michelle L.

Journal:

Expert Opinion on Drug Discovery

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

26

New insights from structural biology into the druggability of G protein-coupled receptors

Jonathan S. Mason, Andrea Bortolato, Miles Congreve, Fiona H. Marshall

Journal:

Trends in Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 3.45 MB

english, 2012

27

Discovery of 1,2,4-Triazine Derivatives as Adenosine A 2A Antagonists using Structure Based Drug Design

Congreve, Miles, Andrews, Stephen P., Doré, Andrew S., Hollenstein, Kaspar, Hurrell, Edward, Langmead, Christopher J., Mason, Jonathan S., Ng, Irene W., Tehan, Benjamin, Zhukov, Andrei, Weir, Malcolm,

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.19 MB

english, 2012

28

Detection of Ligands from a Dynamic Combinatorial Library by X-ray Crystallography

Miles S. Congreve, Deborah J. Davis, Lindsay Devine, Cesare Granata, Marc O′Reilly, Paul G. Wyatt, Harren Jhoti

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 229 KB

english, 2003

29

Comparison of orexin 1 and orexin 2 ligand binding modes using X-ray crystallography and computational analysis

Rappas, Mathieu, Ali, Ammar, Bennett, Kirstie A, Brown, Jason D, Bucknell, Sarah J, Congreve, Miles, Cooke, Robert M, Cseke, Gabriella, de Graaf, Chris, Dore, Andrew S, Errey, James C, Jazayeri, Ali,

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 3.39 MB

english, 2019

30

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency §

Edwards, Philip D., Albert, Jeffrey S., Sylvester, Mark, Aharony, David, Andisik, Donald, Callaghan, Owen, Campbell, James B., Carr, Robin A., Chessari, Gianni, Congreve, Miles, Frederickson, Martyn,

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 359 KB

english, 2007

31

Firstâinâman study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M 1 âreceptor partial agonist for the treatment of Dementias

Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Prins, Samantha, Doef, Thalia F., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H.

Journal:

British Journal of Clinical Pharmacology

Year:

2020

File:

PDF, 1.72 MB

2020

32

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

van Montfort, Rob L. M., Congreve, Miles, Tisi, Dominic, Carr, Robin, Jhoti, Harren

Journal:

Year:

2003

Language:

english

File:

PDF, 341 KB

english, 2003

33

Ascidiatrienolide A is a 10-membered lactone

Congreve, Miles S., Holmes, Andrew B., Hughes, Andrew B., Looney, Mark G.

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 265 KB

english, 1993

34

Structure Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu 5 ) X-ray structures

Christopher, John, Orgován, Zoltán, Congreve, Miles, Dore, Andrew S, Errey, James C., Marshall, Fiona H., Mason, Jonathan S., Okrasa, Krzysztof, Rucktooa, Prakash, Serrano-Vega, Maria J., Ferenczy, Gy

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 2.27 MB

english, 2018

35

Comparison of orexin 1 and orexin 2 ligand binding modes using X-ray crystallography and computational analysis

Rappas, Mathieu, Ali, Ammar, Bennett, Kirstie A, Brown, Jason D, Bucknell, Sarah J, Congreve, Miles, Cooke, Robert M, Cseke, Gabriella, de Graaf, Chris, Dore, Andrew S, Errey, James C, Jazayeri, Ali,

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 3.39 MB

2019

36

XâRay Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists.

Jespers, Willem, Verdon, Gregory, Azuaje, Jhonny, Majellaro, MarÃa, KerÃ¤nen, Henrik, GArcÃa-Mera, Xerardo, Congreve, Miles, deFlorian, Francesca, de Graaf, Chris, Zhukov, Andrei, DorÃ©, Andrew S, M

Journal:

Angewandte Chemie International Edition

Year:

2020

File:

PDF, 2.48 MB

2020

37

High-throughput analytical techniques for reaction optimization

Miles S Congreve, Craig Jamieson

Journal:

Drug Discovery Today

Year:

2002

Language:

english

File:

PDF, 75 KB

english, 2002

38

Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors †

Howard, Nigel, Abell, Chris, Blakemore, Wendy, Chessari, Gianni, Congreve, Miles, Howard, Steven, Jhoti, Harren, Murray, Christopher W., Seavers, Lisa C. A., van Montfort, Rob L. M.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 291 KB

english, 2006

39

Synthesis of (+)-Obtusenyne

S. Y. Frankie Mak, Neil R. Curtis, Andrew N. Payne, Miles S. Congreve, Andrew J. Wildsmith, Craig L. Francis, John E. Davies, Sofia I. Pascu, Jonathan W. Burton, Andrew B. Holmes

Journal:

Chemistry - A European Journal

Year:

2008

Language:

english

File:

PDF, 644 KB

english, 2008

40

Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist

Jazayeri, Ali, Rappas, Mathieu, Brown, Alastair J. H., Kean, James, Errey, James C., Robertson, Nathan J., Fiez-Vandal, Cédric, Andrews, Stephen P., Congreve, Miles, Bortolato, Andrea, Mason, Jonathan

Journal:

Year:

2017

Language:

english

File:

PDF, 45 KB

english, 2017

41

XâRay Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists.

Jespers, Willem, Verdon, Gregory, Azuaje, Jhonny, Majellaro, MarÃa, KerÃ¤nen, Henrik, GArcÃa-Mera, Xerardo, Congreve, Miles, deFlorian, Francesca, de Graaf, Chris, Zhukov, Andrei, DorÃ©, Andrew S, M

Journal:

Angewandte Chemie

Year:

2020

File:

PDF, 2.48 MB

2020

42

High-throughput analytical techniques for reaction optimization

Miles S Congreve, Craig Jamieson

Journal:

Drug Discovery Today

Year:

2002

Language:

english

File:

PDF, 75 KB

english, 2002

43

Deal watch: Valuation benefits of structure-enabled drug discovery

Borshell, Nigel, Congreve, Miles

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 158 KB

english, 2011

44

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors

Cho, Young Shin, Angove, Hayley, Brain, Christopher, Chen, Christine Hiu-Tung, Cheng, Hong, Cheng, Robert, Chopra, Rajiv, Chung, Kristy, Congreve, Miles, Dagostin, Claudio, Davis, Deborah J., Feltell,

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 3.61 MB

english, 2012

45

Selective Cleavage of Benzyl Ethers

Congreve, Miles S., Davison, Edwin C., Fuhry, Mary Ann M., Holmes, Andrew B., Payne, Andrew N., Robinson, R. Anthony, Ward, Simon E.

Journal:

Year:

1993

File:

PDF, 156 KB

1993

46

Synthesis of 5-N-Substituted Tetrazole Derivatives of the Potent NK1 Receptor Antagonist GR203040

Congreve, Miles S.

Journal:

Year:

1996

File:

PDF, 165 KB

1996

47

Solid-Phase Development of a 1-Hydroxybenzotriazole Linker for Heterocycle Synthesis Using Analytical Constructs

Scicinski, Jan J., Congreve, Miles S., Jamieson, Craig, Ley, Steven V., Newman, Emma S., Vinader, Victoria M., Carr, Robin A. E.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

48

Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket

Saalau-Bethell, Susanne M., Berdini, Valerio, Cleasby, Anne, Congreve, Miles, Coyle, Joseph E., Lock, Victoria, Murray, Christopher W., O'Brien, M. Alistair, Rich, Sharna J., Sambrook, Tracey, Vinkovi

Journal:

Year:

2014

Language:

english

File:

PDF, 1.66 MB

english, 2014

49

Intracellular allosteric antagonism of the CCR9 receptor

Oswald, Christine, Rappas, Mathieu, Kean, James, Doré, Andrew S., Errey, James C., Bennett, Kirstie, Deflorian, Francesca, Christopher, John A., Jazayeri, Ali, Mason, Jonathan S., Congreve, Miles, Coo

Journal:

Year:

2016

Language:

english

File:

PDF, 8.00 MB

english, 2016

50

[Methods in Enzymology] Fragment-Based Drug Design - Tools, Practical Approaches, and Examples Volume 493 || Fragment Screening of Stabilized G-Protein-Coupled Receptors Using Biophysical Methods

Congreve, Miles

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски